My stategy for dealing with Benezia involves shooting her with a very damaging weapon. A lot of powers aren't very useful on her (she was a preparation for the useless biotics of ME2, I guess) and once you can damage her, it's best to just shoot as quickly as possible, as she doesn't take a lot of effort to bring down considering her damage output, which is the last thing you want to be on the end of. I dunno, I never find Mass Effect's bosses to ever be difficult really. The only tough ones that spring to mind are Hock's gunship with Kasumi's mission (because it takes ****ing forever, and if you make one mistake you're back at the start) and maybe the final boss for Grunt's recruitment mission, because fighting a YMIR mech and respawning Krogan on Insanity is not nice.
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