You can get around that somewhat if you are running a combo amp though a 4x12. My 1x12 combo can be hooked into a 4x12 with all 5 speakers running. Although Im honestly not sure how that would fair with a 2x12 or higher combo amp.
As far as different speakers..lots of people do that. Although other than speakers I would think open or closed back would impact the sound just as much.
edit: I dont think their are many out there but two 32ohm cabs would work.
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