If you ask me... I recommend using Pro Tools for all none VSTi related instruments. If its a real instrument (like guitars, drums, bass, harp, whatever) - use Pro Tools. If its Vox related - Use Pro Tools.
And as for anything synthetic / programmed / sequenced / keyboard / MIDI / synthesizer etc - use either Cubase or Nuendo series (and, yes, despite them seeming similar, they are in fact kinda different. Both sound wise, and especially when it comes to video editing. Though some people may second guess on that one. But i`m too lazy to argue!).
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