There are rules and then there are rules. Some notes will create harmonies together, others won't. There's not that much you can do to change that "rule".
Then you can have rules for making certain kinds of music just like there's a rule on how to write a haiku poem. If you don't follow the rules with the syllables, it's not a haiku .. but it could still be a poem. So it depends.
When it comes to making music in general, a lot of people like to break what they perceive as rules while still making what people would generally call music. So in those cases, I guess they are more like guidelines.
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