I don't know your full roster but I'd say do it if you don't think you can compete for the championship this year. If you do think you can compete and make the trade, I think you're pretty much screwed with those RBs. I'd try to flip a receiver if you're going to go through with this.
From the standpoint of a keeper league though, Matt Ryan is light years ahead of Rivers, and Hopkins looks like he'll be really good as well. Not sure if he'll become a #1, but with Andre there, he'll always have someone to take pressure off him. Nicks looks like he's in a bad situation but he could be interesting because it looks like he could be traded. Could you imagine if he got traded to Detroit (who are looking for a WR)? His value would go through the roof.
Murray is very valuable in keeper leagues, but you also have to look at his injury history. Nicks is injury-prone as well, but Ryan and Hopkins are still very nice pieces without him.
Yes or no answer: do it.
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