I've never been myself, but I am familiar with Baltimore. Looks like one of the venues is Ram's Head...that particular area is usually packed with college-aged kids, so unless you are worried about being accosted by hipsters, I think you should be ok. Depends on where your hotel is as well. Baltimore itself is not really that scary. Well, some parts are...but I think those parts are pretty easy to avoid.
I will say I personally love Ram's Head as a venue...really nice place.
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