This thread is old and dead, but I think it would be great to get some recommendations going. I love to listen to podcasts while working so I'll throw in a few that I've enjoyed:
Bret Easton Ellis used to do a podcast where he interviewed various directers, musicians and actors. It was fun while it lasted.
These days, I'm hugely into the Nerdist podcast, but even more so the You Made It Weird podcast, which is also hosted on the Nerdist site. Both are comedy/interview podcasts. There's a huuuuuuge backlog of episodes to go through, so I'm not running out any time soon.
You Made it Weird:
http://nerdist.com/podcasts/you-made-it-weird-channel/
Nerdist Podcast:
http://nerdist.com/podcasts/nerdist-podcast-channel/
Bret Easton Ellis Podcast:
http://podcastone.com/Bret-Easton-Ellis-Podcast
(seems like there's still sporadic updates)