Down with the Sickness - Disturbed Can't say anything about this song, except that it drew me into Disturbed, and I love it for that. Not my favorite, and definately not the most meaningful song, but without it I wouldn't have Disturbed.
Best of You - Foo Fighters Very important song to me. When it was released I was struggling with a girlfriend and this song seemed to fit perfectly with my mood.
Sanitarium - Metallica Probably my favorite Metallica song; it has the quietness of Nothing else Matters along with the insaneness of Four Horsemen.
Blackbird - Alterbridge First song I listened to off Alterbridge's debut album (Blackbird). Some of the best guitar work I've heard in modern music, so I cherish this song and album.
Mr. Crowley - Ozzy Osbourne This song furthered my admiration of Randy Rhoads. 2 of my favorite solos ever.
Breath - Breaking Benjamin Great song. "You take the breath right out of me/left a hole where my heart should be."
Overburdened - Disturbed One of my favorites from their 3rd album. Its talking about a soldier who has gone to hell for killing someone in combat. He doesn't understand why; he was only following a ruler he thought was just. I don't have the time (nor you to the patience) to explain why this song means so much to me
Crazy Train - Ozzy Osbourne First song I ever heard from Randy Rhoads. *sigh* only the good die young....
One - Metallica Same as Overburdened, really.
Higher - Creed This song was released when I was about 8 or 9, and I think its one of the reasons I got into rock music. Plus its a beautiful song.