You have to take into consideration BPM so we know how fast the song is, and the time signature to know how to accurately read where the beats actually correlate with the speed of the song. I'm not a mathematician but I do remember from talking to a guitar instructor that with imperfect time signatures (4/4, 2/2 and 8/8 most commonly) that straight 16th notes will land directly on the minute mark which I'd assume would make it easier.
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