i know from personal experience that if you're predisposed to depression then psychotropics are generally not a good idea, at least after the initial period of naivety... and as you've mentioned i think these substances should be treated with respect, you get the most out of them that way.
i used to have a to-do list of that sort of thing - never got round to acid and narrowly avoided DMT, which is fortunate otherwise i'd likely be in a padded cell right now. it's a damned shame to think i may go the rest of my life having never experienced either of them
the one possible exception to the rule were these:
Hawaiian baby woodrose - Wikipedia, the free encyclopedia