I am sure you all know, but just making sure when you say 24-48 you are in reference to muscles and not working out in general. For me I love working out 4 days a week, Monday-upper body, Tuesday legs, Thursdays - upper body and friday - legs.
Reasoning behind this: Muscles come in pairs for the most part. When one muscle is flexing the other muscle is stretching. There are muscles that dont really follow this; obliques being one of them. But the major muscles follow this, Back/chest, tricep/bicep, lower back/abs and Quads. I don't seperate quads because when I lift every muscle is being used in both flexing and stretching.
So by doing upper body in 1 day you are working all the major muscle groups along with giving them a good stretch which promotes better muscle growth. Legs in general to the intensity I do them make me more tired and worn out mentally then any upper body routine could. Because of this I like to give them their own day
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