In the absence of any single "event" (asteroid, super-nova, uncontrolled nukes, etc..) I think mankind will continuously adapt to enviornmental changes, natural disasters and bio threats. There will be times many people will die, but the "up side" of that is population reduction. Overpopulation is a threat in itself. Our lives are a "blink of an eye" as far as total history goes, and the future? Nobody really knows.
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