Originally Posted by Freebase Dali

Yea, most girls consider cunt to be the dirty king of all insults to their gender, and [in serious altercations] they themselves will only use it as a last resort against other females if the frequently used "slut" card does not raise the hackles sufficiently.

As far as guys, I don't normally hear it used much within the confines of the male gender. But because we know its effects, it's our trump insult reserved for women who go above and beyond the pissed-you-off scenario.