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I've never tried it but it's supposed to be pretty safe if you don't do anything stupid like drive.
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There are some precautions you should take to avoid a bad trip, but other than that it's a pretty safe drug, or at least safer than people make it out to be. I have friends who have had bad trips though and are still experiencing negative side effects, so it's definitely not a drug to be taken lightly.
For instance, I definitely don't plan on dropping any acid until after I get out of my depression, that is if I do drop acid again in the first place.