this is monumental (techno, electronic, pop, effects, member)

jibber · 12-15-2004, 09:36 PM

Piscataway, N.J. — Researchers at Rutgers University have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a published report.

The drugs, called DAPYs, mimic the virus by changing shape, which enables them to interfere with the way HIV attacks the immune system.

Tests conducted in conjunction with Johnson and Johnson have shown the drug to be easily absorbed with minimal side effects. It also can be taken in one pill, in contrast to the drug ****tails currently taken by many AIDS patients.

“This could be it,” Stephen Smith, the head of the department of infectious diseases at Saint Michael's Medical Center in Newark, said. “We're all looking for the next class of drugs.”

A research team led by Rutgers chemist Eddy Arnold pre-published details of the most promising of the three drugs, known as R278474, last month in the electronic edition of the Journal of Medicinal Chemistry. Full details will be published in the journal in early 2005.

Dr. Arnold, 47, has worked at dismantling the AIDS virus over the last 20 years. He uses X-ray crystallography, a technique to determine the structure of molecules, the smallest particles that can retain all the characteristics of an element or compound.

The research has targeted reverse transcriptase, a submiscroscopic protein composed of two coiled chains of amino acids. It is considered HIV's key protein.

“Reverse transcriptase is very important in the biology of AIDS,” Dr. Smith said. “If you can really inhibit reverse transcriptase, you can stop AIDS.”

The optimism about R278474 stems from its potential to interfere with an enzyme that the virus needs to copy and insert itself into a human cell.

“We're onto something very, very special,” Dr. Arnold said.

Dr. Arnold established his lab at Rutgers' Center for Advanced Biotechnology and Medicine in 1987. His current 30-member research team is partnered with Johnson and Johnson subsidiaries Janssen Pharmaceutica and Tibotec-Virco NV.

An important advancement in Dr. Arnold's research came in 1990 when Belgian scientist Paul Janssen was added to the collaboration. Dr. Janssen, considered a drug pioneer, published a paper that year that described a new drug that blocked reverse transcriptase but caused resistant strains of the virus to pop up too quickly.

Dr. Janssen sought out Dr. Arnold, who used crystallography to detail the structure of RT. Their work ultimately led to the RT inhibitors.

“We may eventually win the war against HIV/AIDS. That would be an extremely rewarding and satisfying outcome,” Dr. Arnold said.

This is really huge, hopefully it works.

covle · 12-16-2004, 06:57 AM

iv seen a fair few of these before. i guess one can only hope its not another hoax.

Moniker · 12-18-2004, 05:37 AM

I viewed this thread expecting it to be about my penis.

I feel duped, because now I'm here and the story applies to my penis in a much less cool way.

David Frost · 12-18-2004, 02:42 PM

where did you find this?

i havent heard a thing about it.

jibber · 12-18-2004, 04:45 PM

^ yeah someone I know sent it to me, someone we know has HIV so he thought it'd be of interest. He didn't say where it was from in the e-mail, but I can try to find it.

Yellow Card · 12-18-2004, 04:51 PM

Quote:

Originally Posted by Moniker

I viewed this thread expecting it to be about my penis.

I feel duped, because now I'm here and the story applies to my penis in a much less cool way.

BAHAHAHAHAHAHAHA

12-15-2004, 09:36 PM	#1 (permalink)
jibber Freeskier Join Date: Jan 2004 Location: Istanbul was Constantinople now it's Istanbul not Constantinople... Posts: 1,536	this is monumental Piscataway, N.J. — Researchers at Rutgers University have developed a trio of drugs they believe can destroy HIV, the virus that causes AIDS, according to a published report. The drugs, called DAPYs, mimic the virus by changing shape, which enables them to interfere with the way HIV attacks the immune system. Tests conducted in conjunction with Johnson and Johnson have shown the drug to be easily absorbed with minimal side effects. It also can be taken in one pill, in contrast to the drug ****tails currently taken by many AIDS patients. “This could be it,” Stephen Smith, the head of the department of infectious diseases at Saint Michael's Medical Center in Newark, said. “We're all looking for the next class of drugs.” A research team led by Rutgers chemist Eddy Arnold pre-published details of the most promising of the three drugs, known as R278474, last month in the electronic edition of the Journal of Medicinal Chemistry. Full details will be published in the journal in early 2005. Dr. Arnold, 47, has worked at dismantling the AIDS virus over the last 20 years. He uses X-ray crystallography, a technique to determine the structure of molecules, the smallest particles that can retain all the characteristics of an element or compound. The research has targeted reverse transcriptase, a submiscroscopic protein composed of two coiled chains of amino acids. It is considered HIV's key protein. “Reverse transcriptase is very important in the biology of AIDS,” Dr. Smith said. “If you can really inhibit reverse transcriptase, you can stop AIDS.” The optimism about R278474 stems from its potential to interfere with an enzyme that the virus needs to copy and insert itself into a human cell. “We're onto something very, very special,” Dr. Arnold said. Dr. Arnold established his lab at Rutgers' Center for Advanced Biotechnology and Medicine in 1987. His current 30-member research team is partnered with Johnson and Johnson subsidiaries Janssen Pharmaceutica and Tibotec-Virco NV. An important advancement in Dr. Arnold's research came in 1990 when Belgian scientist Paul Janssen was added to the collaboration. Dr. Janssen, considered a drug pioneer, published a paper that year that described a new drug that blocked reverse transcriptase but caused resistant strains of the virus to pop up too quickly. Dr. Janssen sought out Dr. Arnold, who used crystallography to detail the structure of RT. Their work ultimately led to the RT inhibitors. “We may eventually win the war against HIV/AIDS. That would be an extremely rewarding and satisfying outcome,” Dr. Arnold said. This is really huge, hopefully it works. __________________ What you've done becomes the judge of what you're going to do -- especially in other people's minds. When you're traveling, you are what you are right there and then. People don't have your past to hold against you. No yesterdays on the road. William Least Heat Moon, Blue Highways Your toughest competitor lives in your head. Some days his name is fear, or pain, or gravity. Stomp his ass. HOOKED ON THE WHITE POWDER

12-16-2004, 06:57 AM	#2 (permalink)
covle Music Addict Join Date: Jun 2004 Location: melbourne australia Posts: 334	iv seen a fair few of these before. i guess one can only hope its not another hoax. __________________ LIVE.LOVE.BURN.DIE. whoa...i quoted atreyu, that means im hardcore. look how hardcore i am!! thats hardcore...XXX

12-18-2004, 05:37 AM	#3 (permalink)
Moniker Groupie Join Date: Dec 2004 Posts: 8	I viewed this thread expecting it to be about my penis. I feel duped, because now I'm here and the story applies to my penis in a much less cool way. __________________ I find it kinda funny, I find it kinda sad... The dreams in which I'm dying are the best I've ever had.

12-18-2004, 04:45 PM	#5 (permalink)
jibber Freeskier Join Date: Jan 2004 Location: Istanbul was Constantinople now it's Istanbul not Constantinople... Posts: 1,536	^ yeah someone I know sent it to me, someone we know has HIV so he thought it'd be of interest. He didn't say where it was from in the e-mail, but I can try to find it. __________________ What you've done becomes the judge of what you're going to do -- especially in other people's minds. When you're traveling, you are what you are right there and then. People don't have your past to hold against you. No yesterdays on the road. William Least Heat Moon, Blue Highways Your toughest competitor lives in your head. Some days his name is fear, or pain, or gravity. Stomp his ass. HOOKED ON THE WHITE POWDER