FFVII soundtrack is way up there for me , it just great , get the chills from the mako reactor song,

http://i57.tinypic.com/29c4bhw.jpg

Binding of Isaac OST

Honestly, with the environment of being in a basement that this game presents, the soundtrack goes just perfectly with it. The boss battles have badass music, and it really makes it that much more appealing of a game.

So I can't find a youtube vid but the first Road Rash game for Playstation 1 had a great soundtrack to go with the game.

My favorites would be
Final fantasy
Touhou
Ragnarok Online
Skyrim
World of Warcraft & diablo 3

TERA and Zelda had some decent music too, and I've heard guild wars is excellent but I havn't played it.

My Fav videogame soundtracks are in the old Ninja gaiden and Megaman games.



I also like the Metal gear, Fallout and Mass effect soundtrack.
Oh, also the ff7 and ff10 soundtrack..

Yes! The original MGS had some great music IIRC.

http://upload.wikimedia.org/wikipedi...oFuturebox.jpg
Jet Set Radio Future

I freaking love the soundtrack to this game. Honestly, half the enjoyment I got out of the game was due to how well the game play and the soundtrack fit together.

It's kind of like the first game's soundtrack, but with more rock/metal.

Big fan of Andrew Haym - he produces a lot of video game related soundtracks. Check him out on YouTube, a lot of his stuff is posted there.

Hitman: Blood Money, Half Life 1, Silent Hill 2 and 3, Bully, and Tekken 6.