That would work. Depending on who was playing it.

hammond b3 organ

You cant beat a good blues harp :yeah:

Hard to beat a Fender Strat for some blues. Many variable instuments to use for that great Blues sound though. Each musician having a different approach and making it their own.

I was always under the impression guitar = blues. It's the only instrument you can really create blues entirely of(well, I guess apart from maybe piano but that's a very different kind of blues that very quickly bridges into jazz).

Should clear up the controversy

acoustic guitar

With a brass slide and a few strings slightly out of tune.

Such a good video/song.

Acoustic Steel-Stringed Guitars can be 6-string or 12-string guitars. These guitars have a wide variety of sound variations from a brassy, folk style to a fuller, more driving sound. The quality of the guitar, body shape and the types of wood used each combine to determine where the instrument falls along the spectrum.

Source: What are the Different Types of Guitars?